Dapsone(diamino-diphenyl sulphone) is an pharmacological medication most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). As an antibacterial, dapsone inhibits bacterial synthesis of dihydrofolic acid. Though structurally distinct from dapsone, the sulfonamide group of antibacterial drugs also work in this way. When used for the treatment of skin conditions in which bacteria do not have a role, the mechanism or action of dapsone is less well understood. As well as being used in leprosy dapsone can also be used to treat dermatitis herpetiformis and other skin conditions including lichen planus. It is also sometimes used to prevent Pneumocystis pneumonia(PCP) in patients with HIV and to treat idiopathic thrombocytopenic purpura. It is used prophylactically to prevent Pneumocystis pneumonia and toxoplasmosis in patients unable to tolerate trimethoprim with sulfamethoxazole.[1][1]
Dapsone
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